Epitalon Research References

Every claim on this site is cited to a peer-reviewed primary source. The full reference list for the epitalon literature reviewed here — 25 entries, all with PubMed URLs, DOIs where available, and PMIDs for direct verification.

FULL LIST / ALL 25 CITATIONS

Full Citation List

All citations are drawn from the published epitalon literature. PMIDs are resolvable at pubmed.ncbi.nlm.nih.gov. DOIs confirmed in journal records.

#	Authors	Title	Journal / Year	ID
1	Khavinson VKh, Bondarev IE, Butyugov AA	Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells	Bull Exp Biol Med, 2003	PMID 12937682
2	Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD	Peptide promotes overcoming of the division limit in human somatic cell	Bull Exp Biol Med, 2004	PMID 15455129
3	Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV	Effect of epitalon on the lifespan increase in Drosophila melanogaster	Mech Ageing Dev, 2000	PMID 11087911
4	Anisimov VN, Khavinson VKh, et al.	Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice	Biogerontology, 2003	PMID 14501183
5	Anisimov VN, Khavinson VKh, et al.	Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats	Cancer Letters, 2002	PMID 12049808
6	Kossoy G, Zandbank J, Tendler E, et al.	Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa	Int J Mol Med, 2003	PMID 12964022
7	Anisimov VN, Khavinson VKh, et al.	Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice	Int J Cancer, 2002	PMID 12209581
8	Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I	Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice	In Vivo, 2006	PMID 16634527
9	Khavinson VKh, Morozov VG	Peptides of pineal gland and thymus prolong human life	Neuroendocrinology Letters, 2003	PMID 14523363
10	Korkushko OV, Lapin BA, Goncharova ND, et al.	Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people	Advances in Gerontology, 2007	PMID 17969590
11	Khavinson V, Goncharova N, Lapin B	Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys	Neuroendocrinology Letters, 2001	PMID 11524632
12	Korkushko OV, Khavinson VKh, Shatilo VB, Magdich LV	Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people	Bull Exp Biol Med, 2004	PMID 15452611
13	Khavinson VKh, Linkova NS, Kvetnoy IM, et al.	Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture	Bull Exp Biol Med, 2012	PMID 22816096
14	Anisimov VN, Khavinson VKh, et al.	Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice	Bull Exp Biol Med, 2002	PMID 12459848
15	Khavinson VKh, Lezhava TA, Monaselidze JR, et al.	Peptide Epitalon activates chromatin at the old age	Neuroendocrinology Letters, 2003	PMID 14647006
16	Khavinson VKh, Razumovsky MI, et al.	Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa	Neuroendocrinology Letters, 2002	PMID 12195242
17	Yue X, Liu SL, Guo JN, et al.	Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro	Aging (Albany NY), 2022	PMID 35413689
18	Sibarov DA, Vol'nova AB, Frolov DS, Nozdrachev AD	Effects of intranasal administration of epitalon on neuron activity in the rat neocortex	Neurosci Behav Physiol, 2007	PMID 17955380
19	Anisimov VN, Popovich IG, Zabezhinski MA, et al.	Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)	Vopr Onkol, 2005	PMID 15909815
20	Goncharova ND, Vengerin AA, Khavinson VKh, Lapin BA	Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas	Exp Gerontology, 2005	PMID 15664732
21	(Systematic review)	Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties	Int J Mol Sci, 2025	PMID 40141333
22	Al-Dulaimi et al.	Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity	Biogerontology, 2025	PMID 40908429
23	(Research article)	Epitalon-activated telomerase enhances bovine oocyte maturation rate and post-thawed embryo development	Life Sciences, 2025	PMID 39788414
24	(Research article)	The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy	Stem Cell Rev Rep, 2025	PMID 40493162
25	Khavinson VKh, Korneva EA, Malinin VV, et al.	Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress	Neuroendocrinology Letters, 2002	PMID 12500162

SINGLE-SOURCE

The majority of citations (refs 1–20) originate from the Khavinson research group at the St. Petersburg Institute of Bioregulation and Gerontology. Independent Western replication was first published in 2025 (refs 21–24). This provenance is the primary qualifier on all findings derived from this reference set.